Symbol
Name
ID

Myh11
myosin, heavy polypeptide 11, smooth muscle
MGI:102643

Phenotype annotations related to cardiovascular system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Subarachnoid hemorrhage

Bruising susceptibility

Abnormal cardiovascular system morphology

Bicuspid aortic valve

Cardiomegaly

Neoplasm of the heart

Ascending aortic dissection

Aortic aneurysm

Abdominal aortic aneurysm

Thoracic aortic aneurysm

Aortic root aneurysm

Ascending tubular aorta aneurysm

Descending thoracic aorta aneurysm

Aortic dissection

Descending aortic dissection

Aortic rupture

Mucoid extracellular matrix accumulation

Patent ductus arteriosus

Carotid artery dilatation

Carotid artery stenosis

Anterior cerebral artery stenosis

Middle cerebral artery stenosis

Posterior cerebral artery stenosis

Dilatation of the cerebral artery

Moyamoya phenomenon

Coronary artery aneurysm

Coronary artery atherosclerosis

Premature coronary artery atherosclerosis

Coronary artery dissection

Peripheral arterial stenosis

Cystic medial necrosis

Stroke

Ischemic stroke

Transient ischemic attack

Abnormal left ventricular function

Aortic regurgitation

Hypertension

Hypovolemia

Cutis marmorata

Livedo reticularis

Disease(s) Associated with MYH11

megacystis-microcolon-intestinal hypoperistalsis syndrome

patent ductus arteriosus

thoracic aortic aneurysm

Mouse Phenotypes		cardiovascular system phenotype	abnormal vascular regression	dilated heart left ventricle	thin ventricular wall	dilated cardiomyopathy	decreased mean systemic arterial blood pressure	abnormal vascular smooth muscle physiology	increased vascular smooth muscle cell proliferation	decreased vasoconstriction	abnormal vascular wound healing
Availability	Mouse Genotype	cardiovascular system phenotype	abnormal vascular regression	dilated heart left ventricle	thin ventricular wall	dilated cardiomyopathy	decreased mean systemic arterial blood pressure	abnormal vascular smooth muscle physiology	increased vascular smooth muscle cell proliferation	decreased vasoconstriction	abnormal vascular wound healing
	Myh11^tm1.1Dmmz/Myh11^tm1.1Dmmz	*
	Myh11^tm1Bdr/Myh11^tm1Bdr

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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